James Wagner, MBA, PhD
Assistant Professor
218-G National Food Safety and Toxicology
East Lansing MI 48823
Phone: (517) 432-4940
E-mail: wagnerja@msu.edu
Education and Training:
PhD, Pharmacology/Toxicology, Michigan State University, 1998
MBA, Logistics Management, Michigan State University, 1992
BS, Biochemistry, Michigan State University, 1984
Research Interests:
- Pathotoxicology of inflammation: mechanisms of cardiovascular, hepatic, and pulmonary toxicoses
- To develop a research program that integrates molecular, cellular, and physiologic systems and techniques to study inflammatory responses of both humans and animals to pathogen and toxicant exposures
Recent Publications:
Morishita M, Keeler G, Wagner JG, Marsik F, Timm E, Dvonch J, and Harkema J. Pulmonary retention of particulate matter is associated with airway inflammation in allergic rats exposed to air pollution in urban Detroit. 16(10):663-74, 2004.
Harkema JR, Keeler G, Wagner JG, Morishita M, Timm E, Hotchkiss J, Marsik F, Dvonch T, Kaminski N, and Barr E. Effects of concentrated ambient particles on normal and hypersecretory airways in rats. Res. Rep. Health Eff. Inst. (120):1-68; discussion 69-79, 2004.
Dvonch JT, Brook RD, Keeler GJ, Rajagopalan S, D'Alecy LG, Marsik FJ, Morishita M, Yip FY, Brook JR, Timm EJ, Wagner JG, and Harkema JR. Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine. Inhal. Toxicol.16:473-480, 2004.
Wagner JG, Van Dyken SJ, Hotchkiss JA, and JR Harkema. Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways. Toxicol. Sci. 74:437-446, 2003.
Gavett SH, Haykal-Coates N, Highfill JW, Ledbetter AD, Chen LC, Cohen MD, Harkema JR, Wagner JG, and Costa DL. . World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice. Environ. Health Perspect. 111:981-991, 2003.
Wagner JG, Hotchkiss JA, and Harkema JR. Enhancement of nasal inflammatory and epithelialresponses after ozone and allergen coexposure in Brown Norway rats. Toxicol. Sci. 67:284-294, 2002.
Wagner JG, Harkema JR, and Roth RA. Pulmonary leukostasis and inhibition of airway neutrophil recruitment are early events in the endotoxemic rat. Shock. 17:151-158, 2002.
Wagner JG, Van Dyken SJ, Hotchkiss JA, and Harkema JR. Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil dependent in rat nasal epithelium. Toxicol. Sci. 60:338-347, 2001.
Wagner JG, Driscoll KE, and Roth RA. Inhibition of pulmonary neutrophil trafficking during endotoxemia is dependent on the stimulus for migration. Am. J. Respir. Cell Mol. Biol. 20:769-776, 1999.
Wagner JG, Ganey PE, and Roth RA. Nitric oxide is not involved in hepatocyte killing by neutrophils activated by n-formyl-methionyl-leucyl-phenylalanine or phorbol myristate acetate in vitro. Hepatol. 23:803-810, 1996.
