Kathy Meek, DVM
Associate Professor
350 Food Safety & Toxicology Building
East Lansing MI 48823
Phone: (517) 432-9505
E-mail: kmeek@msu.edu
Education and Training:
DVM, Texas A&M University, 1980
Research Interests:
Molecular immunology
Recent Publications:
Ding Q, Reddy YVR, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, and Meek K. Autophosphorylation of the catalytic subunit of the DNA dependent protein kinase is required for efficient end processing during DNA double strand break repair. Mol. Cell .Biol. 23:5836, 2003.
Kilzer JM, Stracker T, Beitzel B, Meek K, Weitzman M, and Bushman FD. Roles of Host Cell Factors in Circularization of Retroviral DNA. Virology. 314:460, 2003.
Yu Y, Wang W, Ding Z, Ye R, Merkle D, Douglas P, Chen D, Schriemer D, Meek K, and Lees-Miller SP. DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair. 2:1239, 2003.
Wechsler T, Chen B, Harper R, Morotomi-Yano K, Huagn BCB, Meek K, Cleaver JE, Chen DJ, and Wable M. DNA-PKcs function regulated specifically by protein phosphatase PP5. Proc. Natl. Acad Sci. USA. 101:1247-52, 2004.
Block W, Merkle D, Meek K, and Lees-Miller SP. Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine. Nuc. Acids Research. 32:1967-1972, 2004.
Reddy V, Ding Q, Lees-Miller SP, Meek K, and Ramsden DA. Nonhomologous end-joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. J. Biol. Chem. 279:39408-39413, 2004.
Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K, and Lees-Miller SP. Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res. 32:4351-7, 2004.
Convery E, Shin EK, Ding Q, Wang W, Douglas, Davis LS, Nickoloff J, Lees-Miller SP, and Meek K. Inhibition of Homologous Recombination by Variants of DNA-PKcs. Proc. Natl. Acad Sci. USA. 102:1345-50, 2005.
Cui X, Yu Y, Gupta S, Lees-Miller SP, and Meek K. Separate clusters of autophosphorylation sites in DNA-PKcs regulate distinct steps in DNA end processing. Mol. Cell. Biol. In press 2005.
Gupta S, and Meek K. The leucine rich region of DNA-PKcs contributes to its innate DNA affinity. Nucleic Acids Res. In press 2005.
