Matti Kiupel, BS, MS, PhD, DACVP
Fachtierarzt für Veterinär Pathologie
Associate Professor
152-A Diagnostic Center for Population and Animal Health
4125 Beaumont Road
Lansing MI 48910-8107
Phone: (517) 432-2670
E-mail: kiupel@dcpah.msu.edu
Education and Training:
PhD, Veterinary Pathology, Purdue University, 2001
MVSc, Veterinary Pathology, Purdue University, 1999
DVM, Humboldt/Freie University, Berlin, Germany, University of Cambridge, UK, and University of Utrecht, NL, 1996
BS, Biology, Humboldt University, Berlin, Germany, 1993
Service Responsibilities:
Section Chief Anatomical Pathology, Head of the Histology and Immunohistochemistry Laboratory, Diagnostic Center for Population and Animal Health
Research Interests:
Cancer research
Diagnosis and prognostic classification of neoplastic diseases of animals
Spontaneous animal models of human cancer
Biomarkers for targeted therapy
Pathogenesis of emerging infectious diseases
Ferret Coronavirus
Feline Calici- and herpesvirus
Staphylococcal enterotoxicosis
WNV and EEE
Development of molecular diagnostic techniques:
Immunohistochemistry
In-situ Hybridization
Laser Capture Microdissection
Image analysis
Recent Publications (selected from more than 100):
Kiupel M, Bostock D, Bergmann V. The prognostic significance of AgNOR counts and PCNA-positive cell counts in canine malignant lymphomas. J Comp Path 119: 407-418, 1998.
Kiupel M, Stevenson GW, Mittal SK, Clark EG, Haines DM. Circovirus-like viral associated disease in weaned pigs in Indiana. Vet Pathol 35: 303-307, 1998.
Kiupel M, Bostock D, Teske E. Prognostic factors for the treatment of canine malignant lymphoma. Vet Pathol 36: 292-300, 1999.
Stevenson GW, Kiupel M, Mittal SK, Kanitz CL, Ultrastructure of porcine circovirus in persistently infected PK-15 cells. Vet Pathol 36: 368-378, 1999.
Williams B, Kiupel M, West K, Raymond JT, Grant CK, Glickmann LT, Coronavirus associated enzootic catarrhal enteritis (ECE) in ferrets (Mustela putorius furo): a review of 120 cases (1993-1998) JAVMA 217: 526-530, 2000.
Kiupel M, Stevenson GW, Latimer KS, Choi J, Kanitz CL, Mittal SK, Viral replication and lesions in BALB/c mice experimentally inoculated with Porcine Circovirus (PCV) isolated from a pig with Postweaning Multisystemic Wasting Disease (PMWS). Vet Path 38: 74-82, 2001.
Ramos-Vara JA, Kiupel M, Miller MA, Diagnostic immunohistochemistry of infectious diseases in dogs and cats. J Histotech 25: 201-214, 2002.
Ramos-Vara JA, del Piero F, Kiupel M, Fitzgerald SD, Bermudez AJ, Johnson GC, Miller MA, Diagnostic immunohistochemistry of equine and avian infectious diseases. J Histotech 25: 215-228, 2002.
Peterson RA, Kiupel M, Capen CC Adrenal Cortical Carcinomas with Myxoid Differentiation in the Domestic Ferret (Mustela putorius furo). Vet Pathol 40: 136-142, 2003.
Fitzgerald SD, Patterson JD, Kiupel M, Simmons HA, Grimes SD, Sarver CF, Fulton RM, Steficek BA, Cooley TM, Massey JP, Sikarskie JG. Clinical and Pathological Features of West Nile Virus Infection in Native North American Owls (Family Strigidae). Avian Dis 47: 602-610, 2003.
Kiupel M, Simmons HA, Fitzgerald SD, Wise A, Sikarskie JG, Cooley TM, Hollamby SR, Maes R. West Nile Virus Infection in Eastern Fox Squirrels (Sciurus ). Vet Pathol 40: 703-707, 2003.
Kiupel M, Webster JD, Kaneene JB, Miller RA, Yuzbasiyan-Gurkan V. The Use of KIT and Tryptase Expression Patterns as Prognostic Tools for Canine Cutaneous Mast Cell Tumors. Vet Pathol 41: 371-377, 2004.
Peterson RA, Kiupel M, Bielinska M, Capen CC Wilson DB. Transcription Factor GATA-4 is a Marker of Anaplasia in Adrenocortical Neoplasms of the Domestic Ferret (Mustela putorius furo) Vet pathol 41:446-449, 2004.
Tai MH, Chang CC, Kiupel M, Webster, JD, Olson LK, Trosko JE. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 26: 495-502, 2005.
Kiupel M, Webster JD, Kaneene JB, Miller RA, Yuzbasiyan-Gurkan V. Impact of tumor depth, tumor location and multiple synchronous masses on the prognosis of canine cutaneous mast cell tumors. J Vet Med A 52: 1–8, 2005.
Ruiz CE, Iemura M, Medie S, Varga P, Van Alstine WG, Mack S, Deligio A, Fearnot N, Beier UH, Pavcnik D, Hijazi ZM, Kiupel M. Transcatheter placement of a low-profile biodegradable pulmonary valve made of small intestinal submucosa: A long-term study in a swine model. J Thorac Cardiovasc Surgery 130: 477-484, 2005.
Reimer SB, Pelosi A, Frank JD, Steficek B A, Kiupel M, Haupman JG. Multiple Endocrine Neoplasia Type I in a Cat. J Am Vet Med Assoc 227: 101-104, 2005.
Mullaney T, Murphy AJ, Kiupel nkM, Bell JA, Rossano MG, Mansfield LS. Evidence that horses are natural intermediate hosts for Sarcocystis neurona. Vet Parasit 133: 27-36, 2005.
Kiupel M, Stevenson GW, Galbreath EJ, North A, HogenEsch H, Mittal SK, Porcine Circovirus type 2 (PCV2) causes apoptosis in experimentally inoculated BALB/c mice. BMC Veterinary Research 2005, 1: 7 (31Oct2005).
Pelosi A, Eyster GE, Déjardin LM, Kiupel M, Rees JL, Richter MA, Olivier NB. Jugular vein graft as a modified Blalock-Taussig procedure. Am J Vet Res. 67: 174-179, 2006.
Webster JD, Yuzbasiyan-Gurkan V, Kaneene JB, Miller RA, Resau JH, Kiupel M. The Role of c-KIT in Canine Cutaneous Mast Cell Tumors: Evaluation of c-KIT’s Role in Tumorigenesis in a Spontaneous Canine Model. Neoplasia 8: 104-111, 2006.
Baszler TV, Kiupel M, Williams ES, Thomsen BV, Gidlewski T, O’Rourke KI. Concordance of Ventana NexESâ and DakoCytomation Autostainer Universal Staining Systemâ for Immunohistochemical Diagnosis of Scrapie in Domestic Sheep and Chronic Wasting Disease in North American White-tailed Deer (Odocoileus virginianus), Mule Deer (Odocoileus hemionus), and Rocky Mountain Elk (Cervus elaphus). JVDI 18: 147-155, 2006.
Webster JD, Kiupel M, Yuzbasiyan-Gurkan V. Evaluation of Kinase Domain c-KIT Mutations in Canine Cutaneous Mast Cell Tumors. BMC Cancer 6: 85, 2006.
Munday JS, Brennan MM, Jabar AM, Kiupel M. Ovine intestinal adenocarcinomas: histologic and phenotypic comparison with human colon cancer. Comp Med 56: 136-141, 2006.
Wise AG, Kiupel M, Maes RK. A Novel Coronavirus Associated with Epizootic Catarrhal Enteritis (ECE) in Ferrets. Virol 349: 164-174, 2006.
Bartner LR, Tesfaigzi Y, Kiupel M, Robinson NE. Persistent mucus accumulation - A consequence of delayed apoptosis in RAO-affected horses? Am J Physiol Lung Cell Mol Physiol 291: 602-609, 2006.
Munday JS, Brennan MX, Kiupel M. Abnormal expression of β-catenin, E-cadherin, COX-2, and p53 protein by ovine intestinal adenocarcinoma cells. Vet Pathol 43: 613–621, 2006.
Rector A, Mostmans S, Van Doorslaer K, McKnight CA, Maes RK, Wise AG, Kiupel M, Van Ranst M. Genetic characterization of the Rousettus aegyptiacus papillomavirus type 1, isolated from a basosquamous carcinoma in an Egyptian fruit bat. Vet Microbiol 117: 267-275, 2006.
Patrick DJ, Fitzgerald SD, Sesterhenn IA, Davis CJ, Kiupel M. Classification of Canine Urinary Bladder Urothelial Tumors Based on the World Health Organization/International Society of Urological Pathology Consensus Classification. J Comp Pathol J Comp Pathol. 135: 190-199, 2006.
McKnight CA, Kiupel M, Wise A, Howe C, Maes R. Papillomavirus-associated basosquamous carcinoma in an Egyptian fruit bat (Rousettus aegypticus) J Zoo Wildlife Med 37: 193-196, 2006.
Garner MM, Ramsell K, Schoemaker NJ, Nordhausen RW, Bolin S, Kiupel M. Myofasciitis in the domestic ferret. Vet Pathol 44: 25-38, 2007.
Chiang SK, Sommer S, Aho A, Kiupel M, Colvin C, Tooker B, Coussens PM. Relationship between Mycobacterium avium subspecies paratuberculosis, IL-1a, and TRAF1 in primary bovine monocyte-derived macrophages, Vet Immunol Immunopathol 116: 131–144, 2007.
Webster JD, Yuzbasiyan-Gurkan V, Miller RA, Kaneene JB, Kiupel M. Cellular Proliferation in Canine Cutaneous Mast Cell Tumors: Associations with c-KIT and its Role in Prognostication. Vet Pathol 44: 298-308, 2007.
Zarfoss, M, Klauss, G, Kiupel, M, Jones, Y, Newkirk, K, Colitz, CMH, Weisbrode, S, Kusewitt, D, Dubielzig, RR. Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study. Vet Pathol 44: 276-284, 2007.
Harrison TM, Sikarskie J, Kruger J, Wise A, Mullaney TP, Kiupel M, Maes RK. Systemic calicivirus epidemic in captive exotic felids. J Zoo Wildl Med 38: 292–299, 2007.
Smedley RC, Patterson JS, Miller RA, Massey JP, Wise AG, Maes RK, Wu P, Kaneene JB, Kiupel M. Sensitivity and Specificity of Monoclonal and Polyclonal Immunohistochemical Staining for West Nile Virus in Various Organs from American Crows (Corvus brachyrhynchus) BMC Infect Dis, 7: 49 (30 May), 2007.
Munday JS, Kiupel M, French A, Howe L, Squires R. Detection of papillomaviral sequences in feline Bowenoid in situ carcinoma using consensus primers. Vet Dermatol 18: 241-245, 2007.
McKnight CA, Maes RK, Wise AG, Kiupel M. Tongue as a sample for the diagnosis of parvoviral infection in dogs and cats. JVDI 19: 409-413, 2007.
Nolen-Walston R, Rushton S, Rodriguez C, Bedenice D, Kiupel M, Del Piero F. Eastern Equine Encephalitis (EEE) in 9 South American Camelids J Vet Int Med 21: 846-852, 2007.
Webster JD, Yuzbasiyan-Gurkan V, Trosko JE, Chang CC, Kiupel M. Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia. Vet Pathol 44: 893-900, 2007.
Schmitt SM, Cooley TM, Fitzgerald SD, Bolin SR, Lim A, Schaefer SM, Kiupel M, Maes RK, Hogle SA, O’Brien DJ. An outbreak of eastern equine encephalitis virus in free-ranging white tailed deer in Michigan. J Wildl Dis 43: 635-644, 2007.
Frank JD, Reimer SB, Kass P, Kiupel M. Clinical Outcomes of Canine Gastrointestinal Lymphoma: A Study of 30 Cases (1997-2004). J Am Anim Hosp Assoc 43: 313-321, 2007.
Garner MM, Ramsell K, Morera N, Juan-Sallés C, Jiménez J, Ardiaca M, Montesinos A, Teifke JP, Löhr CV, Evermann JF, Baszler TV, Nordhausen RW, Wise AG, Maes RK, Kiupel M. Clinico-pathologic features of a disease resembling feline infectious peritonitis in the domestic ferret (Mustela putorius). Vet Pathol 45: 236-246, 2008.
Petersen-Jones SM, Mentzer AL, Dubielzig RR, Render JA, Steficek BA, Kiupel M. Ocular Melanosis in the Cairn Terrier: histopathological description of the condition, and immunohistological and ultrastructural characterization of the characteristic pigment-laden cells. Vet Ophthal 11: 260–268, 2008.
Lee KA, O’Reilly S, Kiupel M, McCormick JJ, LaPres JJ. The role of prolyl hydroxylase domain protein 2 (PHD2/EGLN1) in modulating tumor-forming potential. Mol Cancer Res Mol Cancer Res 6: 829-842, 2008.
Wagner S, Kiupel M, Peterson RA, Heikinheimo M, Wilson DB. Cytochrome b5 Expression in Gonadectomy-induced Adrenocortical Neoplasms of the Domestic Ferret (Mustela putorius furo). Vet Pathol 45: 439-442, 2008.
Ramos-Vara J, Kiupel M (chair), Baszler T, Bliven L, Broderson B, Chelack B, Czub S, Del Piero F, Dial S, Ehrhart EJ, Graham T, Manning L, Paulsen D, Valli VE, West K. AAVLD subcommittee on standardization of immunohistochemistry guidelines for standardization of diagnostic immunohistochemistry in veterinary laboratories. JVDI 2: 393-413, 2008.
Silva LP, Etchebarne BE, Weber Nielsen MS, Liesman JS, Kiupel M, VandeHaar Michael J. Intramammary infusion of leptin decreases proliferation of mammary epithelial cells in prepubertal heifers. J Dairy Sci 91: 3034-44, 2008.
Webster JD, Yuzbasiyan-Gurkan V, Thamm DH, Hamilton E, Kiupel M. Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone. BMC Vet Res 4: 32 2008.
Munday JS, Kiupel M, French A, Howe L. Amplification of papillomaviral DNA sequences from a high proportion of feline cutaneous in situ and invasive squamous cell carcinomas using a nested polymerase chain reaction. Vet Dermatol 18: 241-245, 2008.
Schrenzel MD, Tucker TA, Donovan TA, Busch MD, Wise AG, Maes RK, Kiupel M. New hosts for equine herpesvirus 9. Emerg Infect Dis 14: 1616-1619, 2008.
Kasem S, Yamada S, Kiupel M, Woodruff M, Ohya K, Fukushi H. Equine herpesvirus type 9 in giraffe with encephalitis. Emerg Infect Dis. 14: 1948-1949, 2008.
Munday JS, Willis KA, Kiupel M, Hill FI, Dunowska M. Amplification of three different papillomaviral DNA sequences from a cat with viral plaques. Vet Dermatol. 19: 400-404, 2008.
Kiupel M, Webster JD, Yuzbasiyan-Gurkan V. Prognostic Indicators for Canine Mast Cell Tumors: Margin Evaluation and Histologic Grading. ViVeD, 16 (July edition), 2008.
Webster JD, Kiupel M, Yuzbasiyan-Gurkan V. Prognostic Indicators for Canine Mast Cell Tumors: Proliferation Marker. ViVeD, 16 (July edition), 2008.
Yuzbasiyan-Gurkan V, Kiupel M, Webster JD. The Proto-oncogene KIT in Canine Mast Cell Tumors: Significance in Prognosis. ViVeD, 17 (September edition), 2008.
Neupane M, Chang CC, Kiupel M, Yuzbasiyan-Gurkan V. Isolation and characterization of canine adipose derived mesenchymal stem cells (cAD-MSCs). Tissue Eng Part A, 2008.
Tuntivanich N, Pittler S, Fischer A, Omar G, Kiupel M, Weber A, Steibel JP, Khan NW, Petersen-Jones SM. Caracterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation. IOVS 2008.
Garner MM, Helmick K, Ochsenreiter J, Richman LK, Latimer E, Wise AG, Maes RK, Kiupel M, Nordhausen RW, Zong JC, Hayward GS. Clinico-pathologic Features of Fatal Disease Attributed to New Variants of Endotheliotropic Herpesviruses in Two Asian Elephants (Elephas maximus). Vet Pathol 46: 97-104, 2009.
