Matti Kiupel, BS, MS, PhD, DACVP
Fachtierarzt für Veterinär Pathologie
Associate Professor
152-A Diagnostic Center for Population and Animal Health
4125 Beaumont Road
Lansing MI 48910-8107
Phone: (517) 432-2670
E-mail: kiupel@dcpah.msu.edu
Education and Training:
PhD, Veterinary Pathology, Purdue University, 2001
MVSc, Veterinary Pathology, Purdue University, 1999
DVM, Humboldt/Freie University, Berlin, Germany, University of Cambridge, UK, and University of Utrecht, NL, 1996
BS, Biology, Humboldt University, Berlin, Germany, 1993
Service Responsibilities:
Section Chief Anatomical Pathology, Head of the Histology and Immunohistochemistry Laboratory, Diagnostic Center for Population and Animal Health
Research Interests:
Cancer research
Diagnosis and prognostic classification of neoplastic diseases of animals
Spontaneous animal models of human cancer
Biomarkers for targeted therapy
Pathogenesis of emerging infectious diseases
Ferret Coronavirus
Feline Calici- and herpesvirus
Staphylococcal enterotoxicosis
WNV and EEE
Development of molecular diagnostic techniques:
Immunohistochemistry
In-situ Hybridization
Laser Capture Microdissection
Image analysis
Recent Publications:
Tai MH, Chang CC, Kiupel M, Webster, JD, Olson LK, Trosko JE. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 26: 495-502, 2005.
Kiupel M. Prognostic evaluation of canine cutaneous mast cell tumors: a pathologist’s view. VCS News 29: 1-8, 2005.
Kiupel M, Webster JD, Kaneene JB, Miller RA, Yuzbasiyan-Gurkan V. Impact of tumor depth, tumor location and multiple synchronous masses on the prognosis of canine cutaneous mast cell tumors. J Vet Med A 52: 1–8, 2005.
Ruiz CE, Iemura M, Medie S, Varga P, Van Alstine WG, Mack S, Deligio A, Fearnot N, Beier UH, Pavcnik D, Hijazi ZM, Kiupel M. Transcatheter placement of a low-profile biodegradable pulmonary valve made of small intestinal submucosa: A long-term study in a swine model. J Thorac Cardiovasc Surgery 130: 477-484, 2005.
Reimer SB, Pelosi A, Frank JD, Steficek B A, Kiupel M, Haupman JG. Multiple Endocrine Neoplasia Type I in a Cat. J Am Vet Med Assoc 227: 101-104, 2005.
Mullaney T, Murphy AJ, Kiupel M, Bell JA, Rossano MG, Mansfield LS. Evidence that horses are natural intermediate hosts for Sarcocystis neurona. Vet Parasit 133: 27-36, 2005.
MontianiFerreira F, Fischer A, Cernuda-Cernuda R, Kiupel M, DeGrip WJ, Sherry D, Cho SS, Shaw G, Evans M, Hocking P, PetersenJones S. Detailed histopathologic characterization of the retinopathy, globe enlarged (rge) chick phenotype. Mol Vis 11: 11-27, 2005.
Ruiz CE, Iemura M, Medie S, Varga P, Van Alstine WG, Mack S, Deligio A, Fearnot N, Beier UH, Pavcnik D, Hijazi ZM, Kiupel M. Transcatheter placement of a low-profile biodegradable pulmonary valve made of small intestinal submucosa: A long-term study in a swine model. J Thorac Cardiovasc Surgery 130: 477-484, 2005.
Kiupel M, Stevenson GW, Galbreath EJ, North A, HogenEsch H, Mittal SK, Porcine Circovirus type 2 (PCV2) causes apoptosis in experimentally inoculated BALB/c mice. BMC Veterinary Research 1: 7, 2005.
Munday JS, Richey LJ, Brown CA, Rodriguez NA, Kiupel M. Extramedullary plasmacytoma of the salivary gland in two Syrian hamsters (Mesocricetus auratus). Vet Pathol Vet Pathol 42: 819-823, 2005.
Webster JD, Yuzbasiyan-Gurkan V, Kaneene JB, Miller RA, Resau JH, Kiupel M. The Role of c-KIT in Canine Cutaneous Mast Cell Tumors: Evaluation of c-KIT’s Role in Tumorigenesis in a Spontaneous Canine Model. Neoplasia 8: 104-111, 2006
Webster JD, Kiupel M, Yuzbasiyan-Gurkan V. Evaluation of Kinase Domain c-KIT Mutations in Canine Cutaneous Mast Cell Tumors. BMC Cancer 6: 85, 2006.
Munday JS, Brennan MM, Jabar AM, Kiupel M. Ovine intestinal adenocarcinomas: histologic and phenotypic comparison with human colon cancer. Comp Med 56: 136-141, 2006.
Wise AG, Kiupel M, Maes RK. A Novel Coronavirus Associated with Epizootic Catarrhal Enteritis (ECE) in Ferrets. Virol 349: 164-174, 2006.
Pelosi A, Eyster GE, Déjardin LM, Kiupel M, Rees JL, Richter MA, Olivier NB. Jugular vein graft as a modified Blalock-Taussig procedure. Am J Vet Res. 67: 174-179, 2006.
Jones Y, Wise A, Maes R, Kiupel M. Peliod Hepatocellular Carcinoma in the domesticated ferret (Mustela putorius furo). JVDI 18: 228-231, 2006.
Munday JS, Brennan MX, Kiupel M. Abnormal expression of β-catenin, E-cadherin, COX-2, and p53 protein by ovine intestinal adenocarcinoma cells. Vet Pathol 43: 613–621, 2006.
Simmons HA, Fitzgerald SD, Kiupel M, Rost DR,. Emery RW. T cell lymphoma in a dromedary camel (Camelus dromedarius). J Zoo Wildl Dis 36: 727-731, 2006.
Hoenerhoff MJ, Janovitz E, Richman LK, Murphy DA, Butler TC, Kiupel M. Fatal herpesvirus encephalitis in a reticulated giraffe (Giraffa camelopardalis reticulata). Vet Path 43: 769-772, 2006.
Baszler TV, Kiupel M, Williams ES, Thomsen BV, Gidlewski T, O’Rourke KI. Concordance of Ventana NexESâ and DakoCytomation Autostainer Universal Staining Systemâ for Immunohistochemical Diagnosis of Scrapie in Domestic Sheep and Chronic Wasting Disease in North American White-tailed Deer (Odocoileus virginianus), Mule Deer (Odocoileus hemionus), and Rocky Mountain Elk (Cervus elaphus). JVDI 18: 147-155, 2006.
Hoenerhoff MJ, Janovitz E, Kiupel M. Choroid Plexus Papilloma in a Scottish Highland Cow. J Comp Pathol 2006.
Bartner LR, Tesfaigzi Y, Kiupel M, Robinson NE. Persistent mucus accumulation - A consequence of delayed apoptosis in RAO-affected horses? Am J Physiol Lung Cell Mol Physiol 291: 602-609, 2006.
Rector A, Mostmans S, Van Doorslaer K, McKnight CA, Maes RK, Wise AG, Kiupel M, Van Ranst M. Genetic characterization of the Rousettus aegyptiacus papillomavirus type 1, isolated from a basosquamous carcinoma in an Egyptian fruit bat. Vet Micro 2006.
Patrick DJ, Fitzgerald SD, Sesterhenn IA, Davis CJ, Kiupel M. Classification of Canine Urinary Bladder Urothelial Tumors Based on the World Health Organization/International Society of Urological Pathology Consensus Classification. J Comp Pathol J Comp Pathol. 135: 190-199, 2006.
McKnight CA, Kiupel M, Wise A, Howe C, Maes R. Papillomavirus-associated basosquamous carcinoma in an Egyptian fruit bat (Rousettus aegypticus) J Zoo Wildlife Med 37: 193-196, 2006.
Jones YL, Fitzgerald SD, Sikarske JG, Kiupel M, Murphy A, Grosjean N. Clinical Toxoplasmosis in a Free-ranging mink. J Wildl Dis 42: 865-869, 2006.
Garner MM, Ramsell K, Schoemaker NJ, Nordhausen RW, Bolin S, Kiupel M. Myofasciitis in the domestic ferret. Vet Pathol 44: 25-38, 2007.
Chiang SK, Sommer S, Aho A, Kiupel M, Colvin C, Tooker B, Coussens PM. Relationship between Mycobacterium avium subspecies paratuberculosis, IL-1a, and TRAF1 in primary bovine monocyte-derived macrophages, Vet Immunol Immunopathol 116: 131–144, 2007.
Fitzgerald SD, Duncan AE, Tabaka C, Garner MM, Dieter A, Kiupel M. Ovarian dysgerminomas in two mountain chicken frogs (Leptodactylus fallax) J Zoo Wildlife Med 38: 150-154, 2007.
Webster JD, Yuzbasiyan-Gurkan V, Miller RA, Kaneene JB, Kiupel M. Cellular Proliferation in Canine Cutaneous Mast Cell Tumors: Associations with c-KIT and its Role in Prognostication. Vet Pathol 44: 298-308, 2007.
Zarfoss, M, Klauss, G, Kiupel, M, Jones, Y, Newkirk, K, Colitz, CMH, Weisbrode, S, Kusewitt, D, Dubielzig, RR. Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study. Vet Pathol 44: 276-284, 2007.
Harrison TM, Sikarskie J, Kruger J, Wise A, Mullaney TP, Kiupel M, Maes RK. Systemic calicivirus epidemic in captive exotic felids. J Zoo Wildl Med 38: 292–299, 2007.
Smedley RC, Patterson JS, Miller RA, Massey JP, Wise AG, Maes RK, Wu P, Kaneene JB, Kiupel M. Sensitivity and Specificity of Monoclonal and Polyclonal Immunohistochemical Staining for West Nile Virus in Various Organs from American Crows (Corvus brachyrhynchus) BMC Infect Dis, 7: 49 (30 May), 2007.
Wilson FD, Fitzgerald SD, Kiupel M, Walker RL, Williams CB, Todd DJ. The Occurrence of hepatocellular Carcinoma in an Adult Male Nile Lechwe (Kobus Megaceros) from the Jackson Mississippi Zoo. J Zoo Wildlife Dis 38: 329–332, 2007.
Harrison TM, Sikarskie J, Kitchell B, Rosenstein DS, Flaherty H, Fitzgerald SD, Kiupel M. Treatment of Malignant Lymphoma in an African Lion (Panthera leo). J Zoo Wildl Dis 38: 333–336, 2007.
Munday JS, Kiupel M, French A, Howe L, Squires R. Detection of papillomaviral sequences in feline Bowenoid in situ carcinoma using consensus primers. Vet Dermatol 18: 241-245, 2007.
McKnight CA, Maes RK, Wise AG, Kiupel M. Tongue as a sample for the diagnosis of parvoviral infection in dogs and cats. JVDI 19: 409-413, 2007.
Nolen-Walston R, Rushton S, Rodriguez C, Bedenice D, Kiupel M, Del Piero F. Eastern Equine Encephalitis (EEE) in 9 South American Camelids J Vet Int Med 21: 846-852, 2007.
Webster JD, Yuzbasiyan-Gurkan V, Trosko JE, Chang CC, Kiupel M. Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia. Vet Pathol 44: 893-900, 2007.
Schmitt SM, Cooley TM, Fitzgerald SD, Bolin SR, Lim A, Schaefer SM, Kiupel M, Maes RK, Hogle SA, O’Brien DJ. An outbreak of eastern equine encephalitis virus in free-ranging white tailed deer in Michigan. J Wildl Dis 43: 635-644, 2007.
Frank JD, Reimer SB, Kass P, Kiupel M. Clinical Outcomes of Canine Gastrointestinal Lymphoma: A Study of 30 Cases (1997-2004). J Am Anim Hosp Assoc 43: 313-321, 2007.
Garner MM, Ramsell K, Morera N, Juan-Sallés C, Jiménez J, Ardiaca M, Montesinos A, Teifke JP, Löhr CV, Evermann JF, Baszler TV, Nordhausen RW, Wise AG, Maes RK, Kiupel M. Clinico-pathologic features of a disease resembling feline infectious peritonitis in the domestic ferret (Mustela putorius). Vet Pathol (in press)
Neupane M, Chang CC, Kiupel M, Yuzbasiyan-Gurkan V. Isolation and characterization of canine adipose derived mesenchymal stem cells (cAD-MSCs). Tissue Eng (in press)
Lee KA, O’Reilly S, Kiupel M, McCormick JJ, LaPres JJ. The role of prolyl hydroxylase domain protein 2 (PHD2/EGLN1) in modulating tumor-forming potential. Mol Cancer Res 2007 (in press)
