Jack Harkema, DVM, PhD, DACVP
University Distinguished Professor
212 National Food Safety and Toxicology
East Lansing MI 48823
Phone: (517) 353-8627
E-mail: harkemaj@msu.edu
Education and Training:
PhD, Comparative Pathology, University of California-Davis, 1985
DVM, Michigan State University, 1980
MS, Physiology, Michigan State University, 1977
BS, Biology/Chemistry, Calvin College, 1975
Research Interests:
- Respiratory pathology
- Inhalation toxicology
- Mechanisms of airway epithelial injury, adaptation and repair after exposure to air pollutants
- Toxicologic pathology
- Image analysis
- Morphometry
- Immunohistochemistry
- Upper airway toxicology and pathology
- Comparative pathology
- Airway inflammation
- Scientific and medical illustration
Recent Publications:
Wagner JG, Hotchkiss JA, and Harkema JR. Effects of ozone and endotoxin coexposure on rat airway epithelium: Potentiation of toxicant-induced alterations. Environ. Health Perspect. 109:591-598, 2001.
Wagner JG, Hotchkiss JA, and Harkema JR. Enhancement of nasal inflammatory and epithelial responses after ozone and allergen coexposure in Brown Norway rats. Toxicol Sci. 67(2):284-294, 2002.
Farraj A, Harkema JR, Jan TR, and Kaminski NE. Immune responses in the lung and local lymph node of A/J mice to intranasal sensitization and challenge with adjuvant-free ovalbumin. Toxicol. Pathol. 31:432-447, 2003.
Gavett SH, Haykal-Coates N, Highfill JW, Ledbetter AD, Chen LC, Cohen MD, Harkema JR, Wagner JG, and Costa DL. World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice. Environ. Health Perspect. 111(7):981-991, 2003.
Wagner JG, Van Dyken SJ, Wierenga JR, Hotchkiss JA, and Harkema JR. Ozone exposure enhances endotoxin-induced muous cell metaplasia in rat pulmonary airways. Toxicol. Sci. 74:437-446, 2003.
Farraj AK, Harkema JR, and Kaminski NE. Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicol. Sci. 79(2):315-325, 2004.
Mall M, Grubb BR, Harkema JR, O'Neal WK, and Boucher RC. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat. Med. 10(5):487-493, 2004.
Dvonch JT, Brook RD, Keeler GJ, Rajagopalan S, D'Alecy LG, Marsik FJ, Morishita M, Yip FY, Brook JR, Timm EJ, Wagner JG, and Harkema JR. Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine. Inhal. Toxicol. 16(6-7):473-80, 2004.
Harkema JR, Keeler G, Wagner J, Morishita M, Timm E, Hotchkiss J, Marsik F, Dvonch T, Kaminski N, and Barr E. Effects of concentrated ambient particles on normal and hypersecretory airways in rats. Res. Rep. Health Eff. Inst. 120: 1-68, 2004.
Harris JF, Fischer MJ, Hotchkiss JR, Monia BP, Randell SH, Harkema JR, and Tesfaigzi Y. Bcl-2 Sustains Increased Mucous and Epithelial Cell Numbers in Metaplastic Airway Epithelium. Am. J. Respir. Crit. Care Med. 171(7):764-72, 2005.
