Alison Bauer, PhD
Department of Pathobiology & Diagnostic Investigation
B-43 National Food Safety & Toxicology
East Lansing MI 48824
Phone: (517) 884-2075
E-mail: akbauer@msu.edu
Education and Training
1994 B.S., Biochemistry,
Pennsylvania State University, University Park, PA.
2000 Ph.D., Pharmacology, University of Colorado Health
Sciences Center, Denver, CO., 2000.
2002-2006 NIH Intramural Training Fellow, Laboratory of Respiratory
Biology, NIEHS, NIH, Research Triangle Park, NC.
2000-2002 Postdoctoral Fellow, Department of Biochemistry and Molecular
Genetics, CIIT Centers for Health Research, Research Triangle Park, NC.
Research Interests
Role of the innate immune system in mouse and human pulmonary inflammation and tumorigenesis.
Mechanisms of environmental lung carcinogenesis, such as particle-induced carcinogenesis.
Chemoprevention of lung carcinogenesis.
Mechanisms downstream of TLR4 in ozone-induced lung injury/inflammation.
Invited Review
*Bauer, A.K.," Malkinson, A.M., and Kleeberger, S.R. Similar genes may regulate susceptibilities to neoplastic and non-neoplastic pulmonary diseases in mice. *Am. J. Physiol, *287:L685-L703, 2004.**
Recio, L., *Bauer, A.K.," and Faiola, B. Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity. *Chemico-Biological Interactions, *153-154:159-64, 2005.
Recent Publications
*Bauer, A.K.* The role of inflammation in lung neoplasia. *ACVP and ASCVP Conference Proceedings*, 345-349, 2007.
* Dahl, M., *Bauer, A.K.," Arredouani, M., Kleeberger, S.R., Soininen, R., Trygvasson, and Kobzik, L. Protection of the lung against inhaled oxidants through scavenging of oxidized lipids by macrophage class A scavenger receptors MARCO and SRAI/II. *J. Clin. Invest.* 2007 Mar 1;117(3):757-764, 2007.
* M. Dahl and A.K.Bauer are co-first authors on this manuscript.
Cho, H.Y., Morgan, D., *Bauer, A.K.* and Kleeberger, S.R. Signal Transduction Pathways of Tumor Necrosis Factor-Mediated Lung Injury Induced by Ozone. *Am. J. Resp. Crit. Care Med.*, 175(8):829-39, 2007.
*Bauer, A.K.,* Dixon, D., DeGraff, L.M., Walker, C., Cho, H.Y., Malkinson, A.M., and Kleeberger, S.R.* *A protective role for toll-like receptor (TLR)-4 in butylated hydroxytoluene (BHT)-induced mouse pulmonary inflammation and tumorigenesis. *Journal Natl. Cancer Inst.*, 97: 1778-1781, 2005.
Dwyer-Nield, L.D., Srebernek, M.C., Barrett, B.S., Ahn, J, Cosper P., Meyer, A.M., Kisley, L.R., *Bauer, A.K.," Thompson, D.C., and Malkinson, A.M. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic *vs*. non-tumorigenic mouse lung epithelial cell lines. *Carcinogenesis *26:1196-1206, 2005.
*Bauer, A.K.," Faiola, B., Abernethy, D.J., Marchan, R., Pluta, L.J., Wong, V.A., Roberts, K., Jaiswal, A.K., Gonzalez, F.J, Butterworth, B., and Recio, L. Genetic susceptibility to benzene-induced toxicity: role of NAD(P)H oxidoreductase-1 (NQO1). *Cancer Research, *63(5):929-35, 2003.
*Bauer, A.K.," Faiola, B., Abernethy, D.J., Marchan, R., Pluta, L.J., Wong, V.A., Roberts, K., Jaiswal, A.K., Gonzalex, F.J, Butterworth, B., and Recio, L. Role of microsomal epoxide hydrolase (mEH) in genetic susceptibility to benzene-induced toxicity. *Toxicological Science, *72: 201-209, 2003.
Faiola, B., *Bauer, A.K.," Fuller, E.S., Wong, V.A., Pluta, L.J., Abernethy, D.J., Mangum, J., Everitt, J.I, and Recio, L. Variations in *Prkdc* and susceptibililty to benzene-induced toxicity. *Toxicological Sciences *75:321-332 (2003).
Malkinson, A.M., Radcliffe, R., *Bauer, A.K.* Quantitative Trait Locus (QTL) mapping of susceptibilities to both butylated hydroxytoluene (BHT)-induced lung tumor promotion and pulmonary inflammation in CXB recombinant inbred (RI) strains. *Carcinogenesis. *23: 411-417, 2002.
Kisley, L.R., Barrett, B.S., *Bauer, A.K.," Dwyer-Nield, L.D., Barthel, B., Meyer, A.M., Thompson, D.C., and Malkinson, A.M. iNOS genetic deficiency decreases mouse lung tumorigenesis, but not lung inflammation. *Cancer Research*, 62 (23): 6850-6, 2002.
Kisley, L.R., Barrett, B.S., Dwyer-Nield, L.D., *Bauer, A.K.," Thompson, D.C., and Malkinson, A.M. Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. *Carcinogenesis*, 23(10): 1653-60, 2002.
*Bauer, A.K.," Dwyer-Nield, L.D., Keil, K., Koski, K. and Malkinson, A.M. The role of chronic pulmonary inflammation in lung tumor promotion. *Expt. Lung Res.*, 27: 197-216, 2001.
*Bauer, A.K.," Dwyer-Nield, L.D., Hankin, J.A., Murphy, R.C. and Malkinson, A.M. The lung tumor promoter, butylated hydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByj mice but not in promotion-resistant CXB 4 mice. *Toxicology *169: 1-15, 2001.
*Bauer, A.K.," Dwyer-Nield, L.D. and Malkinson, A.M. High cyclooxygenase
(COX)-1 and 2 in lung tumors. *Carcinogenesis*.21:543-550, 2000.
